The deficiency of miR-31 in CD4+ T cells promotes Treg cell development, leading to the alleviation of EAE and Ang II (Angiotensin II)-induced hypertension in mice, while the overexpression of miR-31 inhibits Treg cell differentiation by targeting Foxp3, Gprc5a, and Protein phosphatase 6c (Ppp6C) that are indispensable for Treg cell development (84, 85). This evidence concerns the gene AGT and hypertensive disorder.