The deficiency of miR-31 in CD4+ T cells promotes Treg cell development, leading to the alleviation of EAE and Ang II (Angiotensin II)-induced hypertension in mice, while the overexpression of miR-31 inhibits Treg cell differentiation by targeting Foxp3, Gprc5a, and Protein phosphatase 6c (Ppp6C) that are indispensable for Treg cell development (84, 85). This evidence concerns the gene AGT and Hypertension.