FOXP3 and systemic lupus erythematosus: Moreover, the level of miR-34a positively correlates with the Th17 lineage-specific transcription factor RORγt but negatively correlates with the mRNA expression of FOXP3 in PBMCs of SLE, which indicates that miR-34a may play a part in the imbalance of Th17/Treg in SLE (126).