MTOR and systemic lupus erythematosus: Although it was reported that the increased expression of miR-183C plays a positive role in driving pathogenic Th17 cell differentiation and autoimmune diseases (57), their studies showed that overexpressing miR-183C in lupus mice reverses the ratio of Th17/Treg by regulating mTOR signaling, thus improving the severity of LN and the survival rate of lupus mice (120).