In Treg cells of new-onset SLE, the expression of miR-326 is increased and negatively correlates with the mRNA expression of Ets-1 and positively correlates with the levels of CRP and anti-C1q antibodies from new-onset SLE patients, suggesting that miR-326 may regulate Treg cell dysfunction via targeting Est-1 in SLE (127). The gene discussed is ETS1; the disease is systemic lupus erythematosus.