ESR1 and hepatocellular carcinoma: Figure 4 showed that the PPI network consisted of 77 nodes and 324 edges. The centralization and heterogeneity of the network were 0.292 and 0.751, respectively. In the PPI network, the nodes with higher degree might play important roles in the pharmacological processes. It demonstrated that 10 key nodes, including ESR1, CASP3, EGFR, AR, CYP3A4, ERBB2, NR3C1, PGR, ADAM17, and MMP2 were likely to be the key targets of HCSCs to inhibit HCC (Supplementary Table 3).