PPARGC1A and acute kidney injury: The impact of histone acetylation over the expression of specific relevant genes in AKI has been also studied, including the nephroprotective genes PGC1α and Klotho, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) and the inflammatory cytokine Interleukine-6 (IL-6), among others (Naito et al., 2009; Li et al., 2010; Ruiz-Andres et al., 2016b).