AKT1 and osteosarcoma: Several studies suggested that FA inhibits proliferation and induces apoptosis via down-regulating PI3K/AKT signaling pathway dose-dependently and exerts anti-cancer properties in some cancer cells, including 143B and MG63 osteosarcoma cells (30, 100, and 150 μM treatment) (Wang et al., 2016) and Caski human cervical carcinoma cells (4–20 μM treatment) (Luo et al., 2020).