APOE and Hypertension: In conclusion, the APOE4 interacted with hypertension status to affect longitudinal changes in brain glucose metabolism among older individual with normal cognition, such that the HTN/APOE4+ group showed a steeper decline in FDG SUVR than other groups (Nos HTN/APOE4-, HTN/APOE4-, and No HTN/APOE4+).