Tang’s study [13] showed that SRSF3 could regulate cellular senescence through TP53 alternative splicing; Ajiro’s study [7] found that SRSF3 could regulate the expression of 60 genes and 20 miRNAs in human osteosarcoma cells by the global profiling of the SRSF3-regulated splicing events; Kuranaga’s study [10] indicated that SRSF3 as a PKM splicer played a positive role in cancer-specific energy metabolism; Gautrey’s study [14] identified SRSF3 could regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling. This evidence concerns the gene ERBB2 and cancer.