To confirm the effects of SRSF3 on cell proliferation and invasion, human CRC LoVo and HCT116 cells stably transfected with SRSF3 shRNA or p-GMLV plasmid and their corresponding control vector were analyzed by CCK-8, soft-agar colony formation assay and transwell invasion assays. This evidence concerns the gene SRSF3 and colorectal carcinoma.