Therefore, the conclusion could be reached that UNC1999 attenuated the methylation of H3K27me3 by inhibiting the expression of EZH2, restored the expression of CDKN1C, and reversed the melanoma cell viability induced by downregulation of lncRNA GAS5 and blocked the oxidative stress and apoptosis of melanoma cells. Here, CDKN1C is linked to melanoma.