Therefore, it could be concluded that overexpression of lncRNA GAS5 inhibits the EZH2 expression by recruiting E2F4 to EZH2 promoter, preventing H3K27 trimethylation, upregulating CDKN1C expression, thereby further inhibiting the melanoma cell viability and facilitating the oxidative stress and apoptosis of melanoma cells. The gene discussed is E2F4; the disease is melanoma.