We found that miR-19a or miR-19b-1 overexpression resulted in decreased IL1B expression in lung cancer and NPC cells, while microglia-derived IL1B triggered p53-mediated cell cycle arrest and apoptosis in neural precursor cells38, indicating that reduced IL1B expression induced by onco-miR-19 might contribute to cancer progression. The gene discussed is TP53; the disease is lung carcinoma.