APOE and early-onset autosomal dominant Alzheimer disease: Eight genes (CELSR2, APOE, LDLR, APOB, TOMM40, ABCG8, PCSK9, and ABO) were associated with coronary artery disease, five with diabetes mellitus type 2 (APOE, TOMM40, SUGP1, ABO, and CILP2) and three with Alzheimer's disease (BCAM, TOMM40, and APOE) (see Table S4).