No other causative mutations associated with ALS were identified in the case 1, while the exome sequencing revealed some variants of benign or uncertain significance including c.1340C>A (p.S447*) in the ABCA7 gene associated with Alzheimer's disease, c.344C>T (p.T115M) in the IGHMBP2 gene associated with distal spinal muscle atrophy, and c.231_243delGCAGCAGCAGCAG (p.Q77Hfs*63) in the TBP gene associated with Parkinson's disease (Table S1). The gene discussed is IGHMBP2; the disease is early-onset autosomal dominant Alzheimer disease.