The expression levels of inflammatory factors, IL‐18, IL‐1β, and TNF‐α in AD patients, were 17.235 ± 3.12 pg/ml, 10.541 ± 2.15 pg/ml, and 21.445 ± 3.65 pg/ml, respectively, which was significantly up‐regulated compared with healthy population (the expression levels of IL‐18, IL‐1β, and TNF‐α were 8.766 ± 1.87 pg/ml, 4.394 ± 0.89 pg/ml, and 12.022 ± 1.87 pg/ml, respectively) (p < .001, p < .001, and p < .001, respectively). This evidence concerns the gene IL18 and Alzheimer disease.