The expression of 26 out of the 74 genes (35.14%) changed oppositely after LINC00152 silencing compared to their characteristic expression in CRC vs. normal tissue (adjusted p < 0.05) indicating that the LINC00152 silencing has a reversal effect on the expression of several genes deregulated in CRC including overexpressed PORCN, KLK6, YES1 proto-oncogene, ITGA6 and STC1 pro-metastatic genes (Fig. 3E) which were found to be down-regulated in LINC00152-silenced SW480 cells. The gene discussed is KLK6; the disease is colorectal carcinoma.