ATXN2 intermediate CAG repeat expansions also increase cytoplasmic protein aggregates and motor neuron (MN) dysfunction and death in C9ORF72 ALS patients (9), and frontotemporal dementia (FTD) phenotypes in C9ORF72 ALS patients are modified by intermediated expansions in ATXN2 (10). This evidence concerns the gene ATXN2 and amyotrophic lateral sclerosis.