The ALS signaling pathway was also annotated in CB of BAC-Q72 mice, represented by Glul, Pik3cd, Capn5, Gria1, Capn6, Cacna1s, Grid2, Slc1a2, Kl and Bid. Western blots for the ALS-related proteins Eaat2, Pcp4 and Tbk1 are discussed immediately above and presented in Figure 4B and C. This evidence concerns the gene CAPN5 and amyotrophic lateral sclerosis.