A strong downregulation of RARRES1 have been found in colorectal carcinoma comparing to benign adenoma and normal colon tissue.14 On the other hand, high expression of RARRES1 in inflammatory breast cancer tissue correlated with shorter survival of patients.15 An immunohistochemical study on distinct types of renal cell tumours suggested a prognostic value of nuclear and cytoplasmic RARRES1 expression.16 The relevance of RARRES1 and AGBL2 expression in conventional RCC is not yet known. The gene discussed is RARRES1; the disease is breast carcinoma.