TMEM192 and neoplasm: RARRES1 is a member of a large protein complex including AGBL2, Eg5/KIF11 and EEY bearing protein (EBI), which is involved in the regulation of tubulin tyrosination/detyrosination cycle in tumour cells.6 Overexpression of RARRES1 in human embryonal kidney (HEK293) cell line reduced, whereas exogenous expression of AGBL2 increased the level of detyrosinated tubulin.6 The α-tubulin detyrosination is associated with tumour progression and poor prognosis.25 Using a yeast two-hybrid system, an interaction between RARRES1 and transmembrane protein 192 (TMEM192) has been demonstrated.