AGBL2 promotes liver cancer growth via increasing a-tubulin detyrosination, enhancing IRGM-regulated autophagy and inhibiting apoptosis.30 Expression of AGBL2 results in α-tubulin detyrosination and cell proliferation of gastric cancer via interaction with latexin.31 In our study, a significant association has been seen between AGBL2 expression and tumour grading, which may correspond to the increased α-tubulin detyrosination and proliferative activity of AGBL2-positive tumour cells. This evidence concerns the gene AGBL2 and liver cancer.