Using multivariate analysis, the cytoplasmic expression or lack of expression of RARRES1 protein was found to be an independent negative prognostic factor indicating 5 times higher risk of cancer relapse (relative risk (RR) = 5.333; 95% confidence interval (CI) = 2.873–9.897; p < 0.001 and RR = 4.791; 95% CI = 2.586–8.876; p < 0.001, respectively). This evidence concerns the gene RARRES1 and cancer.