Taken together our results demonstrate that PBMCs are capable to produce the cytokines of the IL-20 subfamily in response to the prominent mediators of renal diseases, however there is a clear difference between the PBMCs of healthy adults and those of patients with CKD, which may be due to the previous activation of the PBMCs originating from patients with CKD [29]. This evidence concerns the gene IL20 and kidney disorder.