PIK3C2A and neuroleptic malignant syndrome: Neuroleptic malignant syndrome (NMS) is a rare, severe and potentially fatal condition characterized by hyperthermia (> 38 °C), muscle rigidity, changes in mental status (delirium, altered consciousness), increased activity of the autonomic nervous system (tachycardia, diaphoresis, blood pressure elevation), increased levels of creatine phosphokinase (CPK) and leukocytosis [1].