The involvement of the rs35533650 polymorphism of the AT1R gene in the pathogenesis of diabetes complicated with hypertension is also under investigation, and our results suggested that the allele frequency of rs35533650 (χ2 = 5.031, P = 0.025) in diabetic patients with hypertension was significantly different from that in diabetic patients without hypertension (P < 0.05). This evidence concerns the gene AGTR1 and diabetes mellitus.