Secondly, during the first-second trimester, EAT releases higher levels of pro-inflammatory adipokines (RBP4, hs-CRP, fatty acid-binding protein-4, leptin, and visfatin), and lower levels of anti-inflammatory adipokines (omentin-1 and adiponectin); these may participate in the chronic low-grade state of inflammation that has previously been confirmed to be associated with GDM [26, 28]. The gene discussed is ADIPOQ; the disease is gestational diabetes.