We also found a positive association between serum cystatin C levels and the Gensini score independent of eGFR, even after adjustment for established risk factors associated with cardiovascular disease and cystatin C. Niccoli et al. [29] demonstrated that the independent association between cystatin C and CAD severity was superior to that of creatinine or eGFR, and we obtained similar results. This evidence concerns the gene CST3 and cardiovascular disorder.