MYH7 and heart failure: Studies comparing outcomes between patients with MYH7 and MYBPC3 pathogenic variants (the predominant genes associated with HCM) have yielded conflicting results—no significant differences were observed for 2 moderately sized cohorts118, 119 but in the larger SHaRe registry those with MYH7 variants had a higher risk of advanced heart failure and overall composite outcome.102 Furthermore, patients with complex genotypes carrying 2 pathogenic mutations were at greater risk of adverse outcome and sudden cardiac death, irrespective of the genes involved.