To better understand, how chromatin structure responds to BCR cross‐linking, we performed a screening of histone H3 phosphorylation marks induced after anti‐IgM stimulation in primary CLL cells and identified two phospho‐marks (H3T6p and H3T11p) enriched at IEGs and correlated with expression of these genes. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.