Within these centres, CLL cells thrive from the external pro‐survival signals they receive from stromal, nurse‐like cells (NLCs) and T cells leading to unique gene expression profiles with substantial activation of nuclear factor‐kappa B (NF‐κB) and pro‐survival signalling cascades from the B‐cell receptor (BCR) (Burger, 2011; Choi et al., 2016; Herishanu et al., 2011). The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.