But tumor cells under antibody-dependent cell-mediated cytotoxicity might develop evasive pathways to avoid NK cell attack (Hu et al. 2019).Shedding is a good way for cancer cells to remove or avoid the surface expression of ligands such as MICB with the presence of metalloproteases in the tumor microenvironment (Schmiedel and Mandelboim 2018). Here, MICB is linked to cancer.