After multivariable adjustment, an OR of 2.82 ([95% CI 1.86; 4.35], p < 0.0001) for incident atrial fibrillation and an OR of 1.49 ([95% CI 1.13; 1.96], p = 0.0046) for incident cardiovascular disease per 1-SD increase in MR-proANP levels were found. This evidence concerns the gene NPPA and cardiovascular disorder.