To further clarify the expression of LINC00324 based on the classification of breast cancer, decreased expression of LINC00324 was detected in Luminal B, Basal-like, and HER-2 breast cancers as well as ER, PR and Her-2 negative breast cancers, based on analysis of data from the TCGA and GEO databases (Figure 1D-1G). This evidence concerns the gene ESR1 and breast cancer.