For example, circHIPK3 can promote angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p,35 and circ-FOXM1 facilitates cell progression by sponging miR-1304-5p in non-small-cell lung cancer,34 suggesting that the miRNA sponge effect of circRNAs is a vital mechanism. The gene discussed is AGT; the disease is non-small cell lung carcinoma.