Both Abeta‐ and tau pathology contribute to synaptic dysfunction in Alzheimer's disease and exert a detrimental interaction at the synaptic level as reviewed by Forner, Baglietto‐Vargas, Martini, Trujillo‐Estrada, & LaFerla, 2017 (Forner et al., 2017). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.