A RCC specificity of such a mechanism could explain the unique association between high density of CD8+ cells and unfavorable disease outcome in RCC which markedly differs from findings in most other cancer types (i.e., urothelial cancer [41], breast cancer [42], pancreatic carcinomas [43], colorectal cancer [44] and others [50]). This evidence concerns the gene CD8A and renal cell adenocarcinoma.