George et al. analyzed the density of CD8+ cells in patients with locoregional high-risk RCC who were either treated with Sunitinib or Placebo in the S-TRAC trial and found that increased density of CD8+ cells was associated with longer disease free survival in the group of patients treated with Sunitinib, but not in the group treated with Placebo [48]. This evidence concerns the gene CD8A and renal cell adenocarcinoma.