However, urinary PrPC concentrations were positively correlated with serum creatinine (R2, 0.25, p < 0.0001) and inversely correlated with estimated glomerular filtration rates (R2, 0.11, p < 0.01), two markers of renal function (Fig. 7d, e), suggesting that in patients with CKD, chronically injured tubules secrete PrPC and that PrPC concentrations could reflect the severity or the extent of the injury. The gene discussed is PRNP; the disease is chronic kidney disease.