FLT1 and neoplasm: By measuring the volume of tumour xenografts we found that the tumour growth in vivo could significantly inhibited by overexpressing miR-590, while overexpression of VEGFR1/2 or NRP1 partially restored tumour growth, and the overexpression of both VEGFR1/2 and NRP1 completely restored the tumour growth (Fig. 8b).