D-MVD also decreased in the tumour xenografts that overexpressed miR-590; D-MVD was partially restored to the normal level after overexpressing VEGFR1/2 or NRP1, and D-MVD was completely restored to the normal level after overexpressing both VEGFR1/2 and NRP1 (Fig. 8d). This evidence concerns the gene FLT1 and neoplasm.