Apoptotic reactions, including cleavage of caspase and PARP and DNA fragmentation, were also induced by the downregulation of HNRNP A0 and RAB3GAP1, indicating that hnRNP A0 was essential for the accurate alignment of chromatins, which is necessary for mitosis to proceed during cell division; this led to the arrangement of the cell cycle and the avoidance of apoptosis only in cancer cells and not in non-tumorous cells. The gene discussed is HNRNPA0; the disease is cancer.