It is noteworthy that the misalignments of chromosomes at the equatorial plane was markedly increased in cancer cells treated with hnRNP A0 siRNA (18/29 cells, 62.0%) while no abnormal alignment was observed in cancer cells treated with scrambled siRNA (0/13 cells, 0%), indicating that hnRNP A0 is essential for cancer cells to accurately proceed to the mitotic phase (Fig. 2b). The gene discussed is HNRNPA0; the disease is cancer.