The number of tumors was reduced by the downregulation of HNRNP A0 or RAB3GAP1 (Fig. 5i) (efficacy of hnRNP A0 or RAB3GAP1 knockdown described in Supplementary Fig. 16), showing that the hnRNP A0-RAB3GAP1-ZWINT1 cascade is a key tumor-promoting pathway. The gene discussed is HNRNPA0; the disease is neoplasm.