As reported, aliskiren produced good results on certain surrogate end-points in HF setting: BNP (brain natriuretic peptide) levels, N-terminal prohormone of BNP (NT-proBNP) levels, plasma renin activity (PRA), plasma renin concentration (PRC), etc [9] Aliskiren is also reported to have good effects on the renal function, as it can increase renal blood flow, and may prevent the deterioration of renal [10, 11]. Here, REN is linked to hydrops fetalis.