INS and Alzheimer disease: The ICV-STZ mouse model is a non-transgenic mouse model mimicking some aspects of sporadic AD, including neuroinflammation, disruption of tau phosphorylation, insulin signaling, Aβ pathology and cognitive deficits (Nazem et al. 2015; Grunblatt et al. 2007; Salkovic-Petrisic et al. 2006; Chen et al. 2012; Grieb 2016; Zhang et al. 2018).