Our findings provide a direct link between neuroinflammation, as a recognized causing factor of sporadic AD (Krstic and Knuesel 2013), tau phosphorylation, the most important biomarker for AD progression (Braak and Braak 1991) and cognitive deficits as the defining symptom and major driver of disability in AD (Cummings 2005). This evidence concerns the gene MAPT and Alzheimer disease.