CUL4A and hereditary clear cell renal cell carcinoma: For example, one study indicated that uc.134 represses hepatocellular carcinoma development by inhibiting CUL4A-mediated ubiquitination of LATS1 and that uc.416 inhibits miR-153 and promotes epithelial-to-mesenchymal transition in renal cell carcinoma [10, 12].