In line with this, several mutations in ECM-associated, FSGS-causing genes have been described (Collagen 4, Laminin B2, the integrins α-4 and β-3, ApoL1, and Cd151) and the circulating factor suPAR is suggested to promote FSGS by modulation of β-3 integrin signaling [4,43]. The gene discussed is APOL1; the disease is focal segmental glomerulosclerosis.