Obscurin (Obscn; Arhgef30; Cytoskeletal Calmodulin And Titin-Interacting RhoGEF), also upregulated and never associated with FSGS, is a modulator of the cytoskeleton and activator of RhoA [18,19] and might therefore be able to induce FSGS [20]. The gene discussed is RHOA; the disease is focal segmental glomerulosclerosis.