Gene ontology (GO) analysis showed that DE genes between CF patients and controls were overrepresented among genes important for the response to bacterial infection (FDR p-value = 1.2E-05, 19 genes including TLR5, S100A8, S100A12, ILR23R) and leukocyte activation (FDR p-value = 3.4E-04, 11 genes including IL23R, IL4R, CDC80, TBX21) (S3 Table). The gene discussed is S100A12; the disease is bacterial infectious disease.