Cardinal et al. reported that drinking hydrogen-rich water had an inhibitory effect on phosphorylation of ERK, p38 and JNK in a chronic allograft nephropathy model [36]; however, immunochemical staining with phosphorylated-ERK antibody did not show any difference in each group in this study (S2 Fig). Here, MAPK8 is linked to Crouzon syndrome-acanthosis nigricans syndrome.