FUS also directly binds to SMN and associates with SMN complexes [36–39], and FUS knock-out or cytoplasmic mislocalization of ALS-mutant FUS induces cytoplasmic SMN mislocalization and a reduced number of nuclear SMN-containing Gems [31, 36, 38, 39]. The gene discussed is SMN1; the disease is amyotrophic lateral sclerosis.