Moreover, Verdich and colleagues (11), in what is, from our knowledge, the only previous study in which the concentration of appetite-related hormones in reduced-obese individuals after WL was compared with nonobese controls, reported a blunted total GLP-1 secretion in individuals with obesity versus healthy-weight controls, but no difference was seen between reduced-obese individuals (after WL) and controls. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.