Aquaporin 3 (AQP3) with a molecular weight of 30 KDa, is a member of the aquaporin family.12, 13 AQP3 has been reported to be abnormally expressed in several diseases that include breast, prostate, gastric and pancreatic cancers.14, 15, 16, 17 Wang et al. elucidated that AQP3 promoted cell proliferation and enhanced cell apoptosis in squamous cell carcinoma.18 Additionally, Muhammad et al. demonstrated that AQP3 improved cell proliferation, migration, invasion, adherence and response in breast cancer.19 This evidence concerns the gene AQP3 and breast cancer.