The expression of AQP3 was mediated by miR‐874 and inhibited the phosphorylation of PI3K/AKT signaling pathway, which were consistent with the results of Xu et al. in gastric cancer.29 Previous studies have indicated that phosphorylation of PI3K and AKT blocks the transmission of downstream signals to regulate the proliferation of tumor cells. Here, AQP3 is linked to gastric cancer.