ONCOMINE data mining indicated that the expression of DNAJC10, TMX1, PDIA4, PDIA5, PDIA6, P4HB and TXNDC5 was significantly up‐regulated in brain and CNS cancers when compared with normal tissue; however, the expression levels of TMX4 and PDIA2 were higher in normal brain samples than in brain cancer tissues (Figure 2A). This evidence concerns the gene PDIA5 and central nervous system cancer.