Immunohistochemistry staining data suggested that the expression of P4HB, PDIA5, TMX1, PDIA4, PDIA6, DNAJC10, TMX3, ERP44, ERP29, ERP27 and TXNDC5 was positively correlated with glioma grade (Figure 2B and Figure S1), whereas the expression levels of TMX4, PDIA2, TMX2 and CASQ1 were negatively correlated with glioma grade. The gene discussed is TMX4; the disease is central nervous system cancer.