Remarkably, it has been suggested that the GCNT2's metastasis‐promoting effect is mediated through modulation of E‐cad protein levels: the overexpression of GCNT2 decreases E‐cad expression, whereas its down‐regulation induces increased levels of the protein.41 Despite the low number of studies addressing the impact of the E‐cad glycosylation pattern in breast cancer, it is clear that post‐translational modifications can underlie the spreading abilities of breast cancer cells associated with E‐cad dysfunction. This evidence concerns the gene CDH1 and breast carcinoma.