In detail, E‐cad low expression was significantly associated with lymph node status (positive vs negative: odds ratio [OR] 1.55, 95% CI 1.15‐2.10), tumour size (≥2 cm vs <2 cm, OR 1.38, 95% CI 1.18‐1.60), histological grade (II–III vs I: OR 1.44, 95% CI 1.06‐1.96) and TNM stage (T3/T4 vs T1/T2: OR 2.44, 95% CI 1.75‐3.41). This evidence concerns the gene CDH1 and neoplasm.