CDH1 and cancer: In particular, hypermethylation of the CDH1 promoter is the predominant mechanism of E‐cad loss in multiple types of cancer, including breast cancer.18, 19, 20 In this context, Shargh and colleagues21 investigated the association between CDH1 promoter methylation and E‐cad expression in 50 ductal breast cancer cases and their respective paired normal breast samples.