CDH1 and neoplasm: Interestingly, in the majority of these studies, mutations were found in combination with loss of heterozygosity (LOH) at the E‐cad chromosomal locus, spotlighting E‐cad as a tumour suppressor gene.12, 13, 16 Specifically, among the 23 mutations identified by Berx and colleagues,13 21 were found in combination with LOH of the wild typeCDH1locus.