Strikingly, in cases with sentinel lymph node metastasis, CDH1 was the most frequently methylated gene (90%), reinforcing the evidence that CDH1 hypermethylation prevails at a more advanced disease stage.23 Sebova and colleagues24 proposed that CDH1 hypermethylation can be used as a biomarker for potentially metastasizing tumours. The gene discussed is CDH1; the disease is neoplasm.