PRMT5 expression has been studied in various cancer types, in which its level and localization appeared to vary depending on the organs of origin and the histological types41, 45, 46, 47, 48 However, we did not find in MM any correlation between the PRMT5 expression levels or intracellular distribution and the histological grade (data not shown). This evidence concerns the gene PRMT5 and Miyoshi myopathy.