Consistent with our observation that MPP 89 cell growth is unaffected by PRMT5 inhibition (Figure 4A), we did not found changes in E2F1, EZH2, CCNA2, CCNE1 and TS expression (Figure 5B), supporting a critical role of the E2F1‐transcriptional activity in PRMT5‐mediated proliferation specifically in MTAP‐deleted MM cells. Here, EZH2 is linked to Miyoshi myopathy.