E2F1 and neoplasm: E2F1 has previously been found to exert controversial roles in different human cancers, promoting either proliferation or tumour suppression, depending on the context 50 Although E2F1 has been proposed as a therapeutic target and it is an independent prognostic factor for many cancers,51, 52, 53, 54 the role of E2F1 in MM has poorly been investigated.