In this scenario, Takagi et al. (2000) showed that FGF2 regulates the expression of adhesion molecules, i.e., L-selectin and CD11b, on the surface of blood neutrophils, the most abundant inflammatory cells present in the airway of COPD patients (Pesci et al., 1998). The gene discussed is FGF2; the disease is chronic obstructive pulmonary disease.