BRCA2 and Friedreich ataxia: Unsurprisingly, it was found that mutations in PALB2 could cause the appearance of FA subtype N, i.e., FANCN, presented with skin, thumb, heart and kidney abnormalities and growth retardation like other FA subtype, however, the presention of FANCN patients is similar to the phenotype of biallelic BRCA2 mutations and differs from other FA subtypes, most notably with respect to the high risks of childhood solid tumors, particularly Wilms tumor and medulloblastoma (Reid et al., 2007; Xia et al., 2007).