BRCA1 and breast carcinoma: The identified breast cancer susceptibility genes in the FA pathway, including BRCA1, BRCA2, BRIP1, PALB2, and RAD51C, are essential genes involved in HR, the error-free pathway for DSB repair during physiological cell cycle progression, which repairs replication-associated DNA damage (Michl et al., 2016; Wright et al., 2018).