Among these, the single nucleotide polymorphisms (SNPs) significantly related to the development of unilateral arm swelling are those targeting NFKB2, IL10, and IL4. In particular, NFKB2 is a transcription factor involved in a multitude of biological processes, including (but not limited to) angiogenesis, cell proliferation, inflammation, tumorigenesis, and tumor progression (88). Here, NFKB2 is linked to neoplasm.