To confirm the monomeric activation of ALK point mutations that are reported as an oncogene in neuroblastoma patients (7–9), we generated an inducible dimerization construct of DmrB-ALK_mF1174L; a phenylalanine to leucine mutation at amino acid 1174 (DmrB-ALK_mF1174L; Figure 2A, highlighted in violet). The gene discussed is ALK; the disease is neuroblastoma.