These fibroblasts secrete energy metabolites from aerobic glycolysis, like lactate and pyruvate that are absorbed via the monocarboxylate transporter 1 (MCT-1) and consumed in the TCA cycle by the cancer cells, resulting in a proper energy metabolite flow through ATP generation via OxPhos, promoting a higher cancer cell proliferation (127, 131). This evidence concerns the gene SLC16A1 and cancer.