Regrettably, the results indicated that inhibition of MEK/ERK and PI3K/Akt signal pathway played a very slender role in expression of NIS and radioiodide uptake induced by nevirapine or that nevirapine and inhibitors of both signal pathways acted through the same downstream pathway to induce redifferentiation of thyroid cancer cells. The gene discussed is AKT1; the disease is thyroid cancer.