Although many studies identified that the expression levels of OGN would alter in cancers, such as gastric cancer (Lee et al., 2003), colorectal cancer (Hu et al., 2018), and invasive ductal breast carcinoma (Roewer et al., 2011), functional data about how OGN participating in cancer pathology are not enough, and further studies are needed. Here, OGN is linked to gastric cancer.