Although DENV-specific neutralizing antibodies provide protection from viral infection, paradoxically, as the antibody titers wane the pre-existing suboptimal antibodies facilitate DENV entry into Fcγ receptor-bearing cells (9–11), such as dendritic cells, macrophages, and monocytes, which are the major innate immune cells producing inflammatory cytokines including IL-6, TNF-α, and IL-10 during infection, which contributes to the pathogenesis of severe dengue (12, 13). Here, TNF is linked to dengue disease.